干细胞技术基础与应用:胚胎干细胞 相关资料

插图：As Sox2 forms a complex with Oct4 and this complex can bind to DNA, many genes are co-regulated by this gene and Nanog is among the direct targets of such complex [81b, 82, 831. Thestudy of the function of Sox2 in mESC was particularly complex because of redundancy with otherfactors Sox also expressed in these cells. Following conditional inactivation can be considered as apowerful factor stabilising the level of expression of Oct4 [52, 84]. In chicken, we indeed identified the Sox2 but also the Sox3 gene as expressed in non-differentiated cESCs. By using QRT-PCR analysis, we were able to quantify the expression level ofthese two genes in control conditions and during induction of differentiation. Regarding the respective data presented in mouse and in chicken, it appears immediately that fewdata are proportionally obtained in chicken, in particular regarding the gene network present orabsent in these cESC.

干细胞技术基础与应用:胚胎干细胞 作者简介

作者：（印度）德布（Kaushik D.Deb） （印度）多德（Satish M.Totey）

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医学 基础医学 生物学

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