Takehiko Watanabe was born in 1939 in Osaka, Japan. He graduated from Osaka University Medical School in 1963 and Graduate School of the same university and obtained Ph.D. in Department of Biochemistry in 1968. After two years as a research staff in this department, he stayed in University of California, Berkeley and National Institutes of Health, Bethesda, USA for two years each. In 1974 he returned to Japan and moved to Department of Pharmacology of the same medical school and became Associate Prof. in 1978. In 1985, he was promoted to Prof. of Department of Pharmacology, Tohoku University School of Medicine, Sendal, and retired in 2002 and became Prof. Emeritus. He accepted two Chinese graduate students. After retirement, he became a member of Evaluation Center of Medical Education of the same medical school from 2002 to 2004. In 2004, he came back to Osaka and has been a member at Evaluation Center of Education, Nara Institute of Science and Technology, and a consultant at Kinshyukai Group of Hospitals, Osaka.
Since 1975, his main research project has been histamine in the brain and he elucidated the distribution of the histaminergic neuron system and the functions of this neuron by various techniques including PET and gene knockout. He published 250 papers in international journals and 50 reviews. He was a member of Board of Directors of the Japanese Pharmacological Societies for 3 terms and is an Honorary Member of the Society.

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