Classification
  Kinases
  Phosphatases
Structure and catalytic mechanisms
  Kinases
  Phosphatases
Substrate specificity
Regulation
  Kinases
  Phosphatases
Phosphorylation in long-term synaptic plasticity
Kinase/phosphatase complexes in synaptic plasticity
Receptor tyrosine kinases in neuronal function and
  plasticity
Kinases and phosphatases in addiction
SUMMARY
Reversible protein phosphorylation is the most
prominent posttranslational regulatory mechanism
in eukaryotes. Protein kinases catalyze the addition
of a phosphoester group to proteins while protein
phosphatases oppose kinase activity by removing
phosphates. The recent sequencing of numerous
genomes has allowed for the identification and
classification of most if not all kinases and phos-
phatases. Kinases represent a large group of en-
zymes (>500 in humans) and are classified by se-
quence similarity, with most kinases containing a
conserved catalytic domain. Phosphatases are a
smaller group (-140 in humans) and are classified
by their catalytic mechanisms, as well as sequence
similarity. Most kinases and phosphatases contain
domains involved in intramolecular regulation of
the catalytic domain. In contras

 2/2   首页 上一页 1 2

医学 基础医学 生物学

在线阅读