《神经科学百科全书:细胞内转运与细胞骨架(英文版)(影印版)(导读版)》内容简介：什么是百科全书？这一名词来自于两个希腊单词：enkuklios（意思是循环的）和paideia（意思是教育）。在16世纪早期，拉丁手稿的抄写者们将这两个单词合而为一，其在英语中演化为一个单词，意思是具有广泛指导意义的工具书（The American Heritage Dictionary，2000，Boston：Houghton Mifflin，p.589）。从其来源可见，其希腊文原词中蕴含着以探索、综合的方式努力获取知识的含义。无论是拉丁文还是英文，该单词泛指涵盖广泛领域知识的工具书。

细胞内转运与细胞骨架-神经科学百科全书-9 相关资料

插图：Though the E（spl） enhancerincludes high-affinity proneural binding sites, highlevels of proneural protein expression in the prospec-tive SOP cannot independently drive E（spl） geneexpression because in the absence of NotchIC, Su（H）functions as part of a repressor complex that ensuresgenes in the E（spl） complex are not expressed. Insurrounding non-SOP cells of the PNC, whereNotch is activated by the SOP cell, NotchIc makesSu（H） function as an activator to drive E（spl） geneexpression.The Complementary Role of Bearded Family Genesin the E（Spl） ComplexThe E（spl） complex also includes non-bHLH genes ofthe Bearded （Brd） family. Their expression is alsoregulated by Notch activation; however, unlike theE（spl） bHLH genes, they do not inhibit proneuralgene expression. Instead, they interfere with Deltafunction by inhibiting Neuralized mediated endocy-tosis of Delta, a step that is essential for effectiveactivation of Notch in the neighboring cell （Figure 2）.toestablishment of a central biasing mechanism during

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自然科学 生物科学 细胞学

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